Abstract
The synthesis and 5-HT(2A) receptor affinities of 2-substituted-5-aminomethyl-10,11-dihydrodibenzo[a,d]cycloheptene (AMDH) derivatives are described. Comparison of the effects of substitution on affinities allowed assignment of potential binding modes in comparison with DOB-like agonists/antagonists and 3-substituted 1-(aminomethyl)-9,10-dihydroanthracene structures.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cyclopentanes / chemical synthesis
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Cyclopentanes / pharmacology*
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Indicators and Reagents
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Kinetics
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Ligands
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Radioligand Assay
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Receptor, Serotonin, 5-HT2A / drug effects
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Receptor, Serotonin, 5-HT2A / metabolism*
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Serotonin Agents / chemical synthesis*
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Serotonin Agents / pharmacology*
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Structure-Activity Relationship
Substances
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5-aminomethyl-10,11-dihydro-dibenzo(a,d)cycloheptene
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Cyclopentanes
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Indicators and Reagents
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Ligands
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Receptor, Serotonin, 5-HT2A
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Serotonin Agents